National Cholesterol Education Program

Adult Treatment Panel III (ATP III) Guidelines Slide Set

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SLIDE 1: ATP III Guidelines
Benefit Beyond LDL-Lowering: The Metabolic Syndrome as a Secondary Target of Therapy

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SLIDE 2: Metabolic Syndrome
Synonyms

• Insulin resistance syndrome
• (Metabolic) Syndrome X
• Dysmetabolic syndrome
• Multiple metabolic syndrome

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SLIDE 3: Metabolic Syndrome (continued)
Causes

• Acquired causes
  • Overweight and obesity
  • Physical inactivity
  • High carbohydrate diets (>60% of energy intake) in some persons
• Genetic causes

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SLIDE 4: Metabolic Syndrome (continued)
Therapeutic Objectives

• To reduce underlying causes
  • Overweight and obesity
  • Physical inactivity
• To treat associated lipid and non-lipid risk factors
  • Hypertension
  • Prothrombotic state
  • Atherogenic dyslipidemia (lipid triad)

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SLIDE 5: Metabolic Syndrome (continued)
Management of Overweight and Obesity

• Overweight and obesity: lifestyle risk factors
• Direct targets of intervention
• Weight reduction
  • Enhances LDL lowering
  • Reduces metabolic syndrome risk factors
• Clinical guidelines: Obesity Education Initiative
  • Techniques of weight reduction

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SLIDE 6: Metabolic Syndrome (continued)
Management of Physical Inactivity

• Physical inactivity: lifestyle risk factor
• Direct target of intervention
• Increased physical activity
  • Reduces metabolic syndrome risk factors
  • Improves cardiovascular function
• Clinical guidelines: U.S. Surgeon General's Report on Physical Activity

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