| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| CLARK (JEFFERSONVILLE), IN-SCOTT, IN -HSA# 365 | 14 | 348,063 | 4.0 | 4.2 | UNSTABLE |
| WAYNE, IN-FAYETTE, IN -HSA# 385 | 14 | 315,546 | 4.4 | 3.8 | UNSTABLE |
| VERMILION, IL-EDGAR, IL -HSA# 333 | 15 | 393,455 | 3.8 | 3.4 | UNSTABLE |
| BARTHOLOMEW, IN-JACKSON, IN -HSA# 313 | 16 | 486,695 | 3.3 | 3.3 | UNSTABLE |
| DUBOIS, IN -HSA# 394 | 4 | 117,607 | 3.4 | 3.3 | UNSTABLE |
| HOWARD (KOKOMO), IN-CASS, IN -HSA# 364 | 13 | 416,865 | 3.1 | 3.2 | UNSTABLE |
| JEFFERSON (MADISON), IN-DEARBORN, IN -HSA# 321 | 11 | 407,117 | 2.7 | 2.8 | UNSTABLE |
| VIGO (TERRE HAUTE), IN-SULLIVAN, IN -HSA# 311 | 18 | 610,424 | 2.9 | 2.7 | UNSTABLE |
| MONTGOMERY, IN -HSA# 402 | 3 | 108,948 | 2.8 | 2.7 | UNSTABLE |
| MARION (INDIANAPOLIS), IN-HENDRICKS, IN -HSA# 275 | 86 | 3,520,446 | 2.4 | 2.6 |
| VANDERBURGH (EVANSVILLE), IN-GIBSON, IN -HSA# 273 | 25 | 932,527 | 2.7 | 2.5 |
| DELAWARE (MUNCIE), IN-RANDOLPH, IN -HSA# 323 | 13 | 476,735 | 2.7 | 2.5 | UNSTABLE |
| ST. JOSEPH (SOUTH BEND), IN-MARSHALL, IN -HSA# 312 | 24 | 1,011,120 | 2.4 | 2.3 |
| DAVIESS (OWENSBORO), KY-OHIO, KY -HSA# 316 | 10 | 451,822 | 2.2 | 2.2 | UNSTABLE |
| HAMILTON (CINCINNATI), OH-BUTLER, OH -HSA# 270 | 98 | 4,746,174 | 2.1 | 2.1 |
| LAKE (GARY), IN-PORTER, IN -HSA# 308 | 40 | 2,006,407 | 2.0 | 2.1 |
| LAWRENCE, IN-ORANGE, IN -HSA# 329 | 4 | 194,620 | 2.1 | 2.1 | UNSTABLE |
| LA PORTE, IN-STARKE, IN -HSA# 378 | 8 | 400,086 | 2.0 | 2.1 | UNSTABLE |
| ELKHART (ELKHART), IN-KOSCIUSKO, IN -HSA# 349 | 14 | 723,630 | 1.9 | 2.0 | UNSTABLE |
| HENRY (NEW CASTLE), IN-HANCOCK, IN -HSA# 362 | 6 | 306,275 | 2.0 | 1.9 | UNSTABLE |
| GRANT, IN-WABASH, IN -HSA# 389 | 8 | 422,227 | 1.9 | 1.8 | UNSTABLE |
| TIPPECANOE (LAFAYETTE), IN-CLINTON, IN -HSA# 300 | 10 | 681,655 | 1.5 | 1.7 | UNSTABLE |
| MADISON (ANDERSON), IN-HAMILTON, IN -HSA# 390 | 12 | 861,304 | 1.4 | 1.5 | UNSTABLE |
| FLOYD (NEW ALBANY), IN-HARRISON, IN -HSA# 339 | 6 | 428,872 | 1.4 | 1.4 | UNSTABLE |
| KNOX, IN-DAVIESS, IN -HSA# 310 | 5 | 384,332 | 1.3 | 1.1 | UNSTABLE |
| WELLS, IN-JAY, IN -HSA# 332 | 4 | 355,089 | 1.1 | 1.0 | UNSTABLE |
| MONROE (BLOOMINGTON), IN-GREENE, IN -HSA# 341 | 5 | 554,445 | 0.9 | 1.0 | UNSTABLE |
| ALLEN (FORT WAYNE), IN-WHITLEY, IN -HSA# 304 | 12 | 1,460,455 | 0.8 | 0.9 | UNSTABLE |
| BOONE (LEBANON), IN -HSA# 401 | 1 | 129,276 | 0.8 | 0.8 | UNSTABLE |
