| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| ATCHISON, MO-HOLT, MO -HSA# 678 | 4 | 38,254 | 10.5 | 6.9 | UNSTABLE |
| CAMDEN, MO -HSA# 685 | 5 | 99,765 | 5.0 | 4.1 | UNSTABLE |
| AUDRAIN, MO-MONROE, MO -HSA# 666 | 6 | 133,139 | 4.5 | 4.0 | UNSTABLE |
| GRUNDY, MO-MERCER, MO -HSA# 683 | 2 | 42,660 | 4.7 | 2.9 | UNSTABLE |
| MISSISSIPPI, AR-PEMISCOT, MO -HSA# 614 | 6 | 215,885 | 2.8 | 2.8 | UNSTABLE |
| LEE, IA-HANCOCK, IL -HSA# 367 | 6 | 201,973 | 3.0 | 2.4 | UNSTABLE |
| PETTIS, MO-SALINE, MO -HSA# 656 | 7 | 282,997 | 2.5 | 2.2 | UNSTABLE |
| JACKSON (KANSAS CITY), MO-CLAY, MO -HSA# 548 | 70 | 3,335,253 | 2.1 | 2.2 |
| COLE, MO-CALLAWAY, MO -HSA# 581 | 14 | 596,547 | 2.3 | 2.1 | UNSTABLE |
| ST. LOUIS, MO-ST. LOUIS CITY, MO -HSA# 541 | 104 | 5,202,651 | 2.0 | 2.0 |
| CRAIGHEAD, AR-GREENE, AR -HSA# 571 | 14 | 664,539 | 2.1 | 2.0 | UNSTABLE |
| VERNON, MO-CEDAR, MO -HSA# 639 | 2 | 97,224 | 2.1 | 1.9 | UNSTABLE |
| ST. CHARLES (ST. CHARLES), MO-LINCOLN, MO -HSA# 599 | 16 | 968,770 | 1.7 | 1.9 | UNSTABLE |
| BOONE (COLUMBIA), MO-RANDOLPH, MO -HSA# 553 | 11 | 624,240 | 1.8 | 1.8 | UNSTABLE |
| GREENE (SPRINGFIELD), MO-BARRY, MO -HSA# 549 | 29 | 1,631,882 | 1.8 | 1.6 |
| BUCHANAN (ST. JOSEPH), MO-NODAWAY, MO -HSA# 591 | 8 | 463,772 | 1.7 | 1.5 | UNSTABLE |
| ADAIR, MO-SCOTLAND, MO -HSA# 566 | 3 | 149,054 | 2.0 | 1.5 | UNSTABLE |
| JASPER (JOPLIN), MO-NEWTON, MO -HSA# 539 | 10 | 604,055 | 1.7 | 1.5 | UNSTABLE |
| CAPE GIRARDEAU, MO-BUTLER, MO -HSA# 563 | 13 | 923,058 | 1.4 | 1.3 | UNSTABLE |
| INDEPENDENCE, AR-HOWELL, MO -HSA# 574 | 5 | 413,779 | 1.2 | 1.3 | UNSTABLE |
| ADAMS, IL-MARION, MO -HSA# 353 | 5 | 443,461 | 1.1 | 1.0 | UNSTABLE |
| LIVINGSTON, MO-CARROLL, MO -HSA# 657 | 1 | 73,370 | 1.4 | 1.0 | UNSTABLE |
| PHELPS, MO-DENT, MO -HSA# 627 | 2 | 291,345 | 0.7 | 0.8 | UNSTABLE |
| TANEY, MO -HSA# 676 | 1 | 101,758 | 1.0 | 0.7 | UNSTABLE |
| HENRY, MO-ST. CLAIR, MO -HSA# 607 | 1 | 138,008 | 0.7 | 0.5 | UNSTABLE |
| LINN, MO -HSA# 673 | 0 | 41,726 | 0.0 | 0.0 | UNSTABLE |
| MADISON, MO -HSA# 663 | 0 | 34,453 | 0.0 | 0.0 | UNSTABLE |
