| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| WHITE, IL-HAMILTON, IL -HSA# 383 | 347 | 72,844 | 476.4 | 293.4 |
| CAPE GIRARDEAU, MO-BUTLER, MO -HSA# 563 | 2,872 | 923,058 | 311.1 | 263.7 |
| CLINTON, IA-WHITESIDE, IL -HSA# 361 | 1,259 | 381,289 | 330.2 | 259.1 |
| MARION, IL-WASHINGTON, IL -HSA# 358 | 585 | 172,011 | 340.1 | 255.6 |
| MORGAN, IL-GREENE, IL -HSA# 319 | 584 | 171,364 | 340.8 | 252.5 |
| MADISON (ALTON), IL-JERSEY, IL -HSA# 299 | 2,529 | 905,977 | 279.1 | 251.5 |
| KANKAKEE (KANKAKEE), IL-IROQUOIS, IL -HSA# 343 | 1,124 | 400,288 | 280.8 | 251.1 |
| SALINE, IL-HARDIN, IL -HSA# 384 | 455 | 128,052 | 355.3 | 249.0 |
| JEFFERSON, IL-WAYNE, IL -HSA# 335 | 540 | 168,160 | 321.1 | 248.6 |
| VIGO (TERRE HAUTE), IN-SULLIVAN, IN -HSA# 311 | 1,724 | 610,424 | 282.4 | 240.0 |
| MC CRACKEN, KY-GRAVES, KY -HSA# 12 | 1,830 | 614,053 | 298.0 | 237.3 |
| WILL (JOLIET), IL-GRUNDY, IL -HSA# 303 | 2,324 | 1,443,239 | 161.0 | 234.0 |
| COOK (CHICAGO), IL-DU PAGE, IL -HSA# 287 | 42,700 | 20,683,957 | 206.4 | 233.3 |
| VERMILION, IL-EDGAR, IL -HSA# 333 | 1,105 | 393,455 | 280.8 | 227.8 |
| RICHLAND, IL-CLAY, IL -HSA# 351 | 467 | 146,651 | 318.4 | 223.9 |
| ST. CLAIR (BELLEVILLE), IL-RANDOLPH, IL -HSA# 325 | 2,523 | 1,075,746 | 234.5 | 223.8 |
| LA SALLE, IL-BUREAU, IL -HSA# 336 | 1,706 | 573,225 | 297.6 | 221.9 |
| WILLIAMSON, IL-JACKSON, IL -HSA# 331 | 1,415 | 552,558 | 256.1 | 219.0 |
| ROCK ISLAND (MOLINE), IL-HENRY, IL -HSA# 307 | 1,782 | 670,642 | 265.7 | 218.0 |
| LEE, IA-HANCOCK, IL -HSA# 367 | 579 | 201,973 | 286.7 | 215.9 |
| KNOX, IL-WARREN, IL -HSA# 324 | 686 | 223,714 | 306.6 | 215.6 |
| KANE (AURORA), IL-DE KALB, IL -HSA# 373 | 2,387 | 1,548,909 | 154.1 | 212.2 |
| DES MOINES, IA-HENRY, IA -HSA# 340 | 572 | 211,988 | 269.8 | 207.1 |
| KNOX, IN-DAVIESS, IN -HSA# 310 | 982 | 384,332 | 255.5 | 204.4 |
| VANDERBURGH (EVANSVILLE), IN-GIBSON, IN -HSA# 273 | 2,126 | 932,527 | 228.0 | 204.0 |
| EFFINGHAM, IL-FAYETTE, IL -HSA# 363 | 399 | 165,911 | 240.5 | 201.2 |
| MONTGOMERY, IL-MACOUPIN, IL -HSA# 334 | 673 | 240,398 | 280.0 | 200.4 |
| DUBUQUE (DUBUQUE), IA-STEPHENSON, IL -HSA# 302 | 1,321 | 536,666 | 246.1 | 199.4 |
| WINNEBAGO (ROCKFORD), IL-LEE, IL -HSA# 291 | 2,308 | 1,173,086 | 196.7 | 189.4 |
| MC LEAN (BLOOMINGTON), IL-DE WITT, IL -HSA# 338 | 1,033 | 580,208 | 178.0 | 188.4 |
| SANGAMON (SPRINGFIELD), IL-MC DONOUGH, IL -HSA# 318 | 2,162 | 1,003,402 | 215.5 | 183.6 |
| PEORIA (PEORIA), IL-TAZEWELL, IL -HSA# 277 | 2,419 | 1,138,763 | 212.4 | 179.8 |
| ADAMS, IL-MARION, MO -HSA# 353 | 1,122 | 443,461 | 253.0 | 176.8 |
| CHAMPAIGN (CHAMPAIGN), IL-COLES, IL -HSA# 279 | 1,278 | 801,910 | 159.4 | 171.4 |
| MACON (DECATUR), IL-SHELBY, IL -HSA# 305 | 1,108 | 503,483 | 220.1 | 171.3 |
