| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| CLARK (JEFFERSONVILLE), IN-SCOTT, IN -HSA# 365 | 877 | 348,063 | 252.0 | 261.1 |
| VIGO (TERRE HAUTE), IN-SULLIVAN, IN -HSA# 311 | 1,724 | 610,424 | 282.4 | 240.0 |
| DELAWARE (MUNCIE), IN-RANDOLPH, IN -HSA# 323 | 1,191 | 476,735 | 249.8 | 235.6 |
| LAKE (GARY), IN-PORTER, IN -HSA# 308 | 4,098 | 2,006,407 | 204.2 | 230.4 |
| WAYNE, IN-FAYETTE, IN -HSA# 385 | 857 | 315,546 | 271.6 | 228.8 |
| VERMILION, IL-EDGAR, IL -HSA# 333 | 1,105 | 393,455 | 280.8 | 227.8 |
| FLOYD (NEW ALBANY), IN-HARRISON, IN -HSA# 339 | 939 | 428,872 | 218.9 | 226.7 |
| MONTGOMERY, IN -HSA# 402 | 271 | 108,948 | 248.7 | 226.5 |
| GRANT, IN-WABASH, IN -HSA# 389 | 1,074 | 422,227 | 254.4 | 224.8 |
| MARION (INDIANAPOLIS), IN-HENDRICKS, IN -HSA# 275 | 6,978 | 3,520,446 | 198.2 | 223.0 |
| HENRY (NEW CASTLE), IN-HANCOCK, IN -HSA# 362 | 664 | 306,275 | 216.8 | 215.4 |
| JEFFERSON (MADISON), IN-DEARBORN, IN -HSA# 321 | 859 | 407,117 | 211.0 | 215.2 |
| DAVIESS (OWENSBORO), KY-OHIO, KY -HSA# 316 | 1,002 | 451,822 | 221.8 | 213.1 |
| BARTHOLOMEW, IN-JACKSON, IN -HSA# 313 | 1,011 | 486,695 | 207.7 | 212.9 |
| LA PORTE, IN-STARKE, IN -HSA# 378 | 848 | 400,086 | 212.0 | 212.2 |
| WELLS, IN-JAY, IN -HSA# 332 | 811 | 355,089 | 228.4 | 207.0 |
| LAWRENCE, IN-ORANGE, IN -HSA# 329 | 454 | 194,620 | 233.3 | 207.0 |
| ALLEN (FORT WAYNE), IN-WHITLEY, IN -HSA# 304 | 2,776 | 1,460,455 | 190.1 | 206.7 |
| DUBOIS, IN -HSA# 394 | 252 | 117,607 | 214.3 | 206.5 |
| KNOX, IN-DAVIESS, IN -HSA# 310 | 982 | 384,332 | 255.5 | 204.4 |
| VANDERBURGH (EVANSVILLE), IN-GIBSON, IN -HSA# 273 | 2,126 | 932,527 | 228.0 | 204.0 |
| ST. JOSEPH (SOUTH BEND), IN-MARSHALL, IN -HSA# 312 | 2,161 | 1,011,120 | 213.7 | 200.1 |
| HAMILTON (CINCINNATI), OH-BUTLER, OH -HSA# 270 | 9,007 | 4,746,174 | 189.8 | 199.4 |
| HOWARD (KOKOMO), IN-CASS, IN -HSA# 364 | 871 | 416,865 | 208.9 | 198.9 |
| TIPPECANOE (LAFAYETTE), IN-CLINTON, IN -HSA# 300 | 1,229 | 681,655 | 180.3 | 197.2 |
| MONROE (BLOOMINGTON), IN-GREENE, IN -HSA# 341 | 917 | 554,445 | 165.4 | 189.7 |
| ELKHART (ELKHART), IN-KOSCIUSKO, IN -HSA# 349 | 1,204 | 723,630 | 166.4 | 183.3 |
| MADISON (ANDERSON), IN-HAMILTON, IN -HSA# 390 | 1,325 | 861,304 | 153.8 | 180.7 |
| BOONE (LEBANON), IN -HSA# 401 | 222 | 129,276 | 171.7 | 162.8 |
