| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| HOUGHTON, MI-BARAGA, MI -HSA# 359 | 547 | 139,002 | 393.5 | 319.1 |
| ALPENA, MI-PRESQUE ISLE, MI -HSA# 371 | 753 | 197,654 | 381.0 | 273.9 |
| LUCAS (TOLEDO), OH-MONROE, MI -HSA# 276 | 6,221 | 2,378,683 | 261.5 | 269.6 |
| GENESEE (FLINT), MI-LAPEER, MI -HSA# 328 | 3,525 | 1,566,939 | 225.0 | 265.1 |
| ST. CLAIR (PORT HURON), MI-SANILAC, MI -HSA# 297 | 1,512 | 600,730 | 251.7 | 254.2 |
| WAYNE (DETROIT), MI-OAKLAND, MI -HSA# 274 | 31,694 | 13,560,555 | 233.7 | 253.8 |
| WEXFORD, MI-OSCEOLA, MI -HSA# 317 | 623 | 224,663 | 277.3 | 251.9 |
| BAY (BAY CITY), MI-OGEMAW, MI -HSA# 342 | 1,558 | 546,082 | 285.3 | 248.5 |
| DICKINSON, MI-MARINETTE, WI -HSA# 315 | 1,206 | 337,961 | 356.8 | 247.5 |
| CRAWFORD, MI-OTSEGO, MI -HSA# 392 | 539 | 176,315 | 305.7 | 245.5 |
| SAGINAW (SAGINAW), MI-HURON, MI -HSA# 322 | 2,264 | 911,585 | 248.4 | 242.5 |
| MUSKEGON (MUSKEGON), MI-MASON, MI -HSA# 296 | 1,897 | 789,604 | 240.2 | 237.0 |
| MARQUETTE, MI-DELTA, MI -HSA# 293 | 999 | 379,993 | 262.9 | 236.1 |
| EMMET, MI-CHEBOYGAN, MI -HSA# 294 | 967 | 373,657 | 258.8 | 233.1 |
| CALHOUN (BATTLE CREEK), MI-BARRY, MI -HSA# 381 | 1,357 | 581,719 | 233.3 | 231.2 |
| MIDLAND (MIDLAND), MI-ISABELLA, MI -HSA# 330 | 1,214 | 578,515 | 209.8 | 226.2 |
| JACKSON (JACKSON), MI-LENAWEE, MI -HSA# 375 | 2,265 | 1,028,913 | 220.1 | 223.6 |
| KENT (GRAND RAPIDS), MI-MONTCALM, MI -HSA# 309 | 4,317 | 2,237,374 | 192.9 | 219.5 |
| BERRIEN (BENTON HARBOR), MI-VAN BUREN, MI -HSA# 327 | 1,872 | 857,081 | 218.4 | 208.0 |
| ONEIDA, WI-GOGEBIC, MI -HSA# 284 | 903 | 294,480 | 306.6 | 207.3 |
| GRAND TRAVERSE, MI-MANISTEE, MI -HSA# 271 | 1,129 | 497,639 | 226.9 | 204.8 |
| KALAMAZOO (KALAMAZOO), MI-ST. JOSEPH, MI -HSA# 348 | 1,542 | 871,317 | 177.0 | 189.0 |
| OTTAWA (HOLLAND), MI-ALLEGAN, MI -HSA# 320 | 1,489 | 962,367 | 154.7 | 188.6 |
| INGHAM (LANSING), MI-SHIAWASSEE, MI -HSA# 285 | 2,373 | 1,566,812 | 151.5 | 186.7 |
