| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| LEFLORE, MS-BOLIVAR, MS -HSA# 487 | 1,147 | 370,904 | 309.2 | 342.4 |
| WILKINSON, MS -HSA# 525 | 101 | 27,630 | 365.5 | 331.9 |
| LAWRENCE, MS-JEFFERSON DAVIS, MS -HSA# 504 | 277 | 80,426 | 344.4 | 330.4 |
| WASHINGTON, MS-SHARKEY, MS -HSA# 488 | 623 | 221,495 | 281.3 | 320.7 |
| HARRISON (BILOXI), MS-HANCOCK, MS -HSA# 456 | 1,849 | 685,416 | 269.8 | 305.9 |
| ADAMS, MS-CONCORDIA, LA -HSA# 435 | 755 | 235,681 | 320.3 | 299.2 |
| FORREST, MS-COVINGTON, MS -HSA# 409 | 1,084 | 453,817 | 238.9 | 279.2 |
| SHELBY (MEMPHIS), TN-PANOLA, MS -HSA# 146 | 7,587 | 3,414,127 | 222.2 | 275.8 |
| WARREN, MS-MADISON, LA -HSA# 431 | 563 | 221,328 | 254.4 | 270.8 |
| HINDS (JACKSON), MS-RANKIN, MS -HSA# 411 | 3,835 | 1,605,126 | 238.9 | 268.6 |
| LINCOLN, MS-COPIAH, MS -HSA# 511 | 479 | 181,139 | 264.4 | 250.6 |
| YAZOO, MS -HSA# 533 | 205 | 76,057 | 269.5 | 244.2 |
| LAUDERDALE, MS-NEWTON, MS -HSA# 412 | 1,470 | 556,789 | 264.0 | 243.7 |
| JONES, MS-WAYNE, MS -HSA# 455 | 877 | 348,745 | 251.5 | 240.6 |
| COAHOMA, MS-QUITMAN, MS -HSA# 422 | 404 | 168,614 | 239.6 | 237.1 |
| PIKE, MS-MARION, MS -HSA# 477 | 684 | 276,525 | 247.4 | 235.6 |
| ST. TAMMANY (SLIDELL), LA-WASHINGTON, LA -HSA# 500 | 1,550 | 817,859 | 189.5 | 231.9 |
| JACKSON (PASCAGOULA), MS-GEORGE, MS -HSA# 471 | 767 | 444,743 | 172.5 | 229.3 |
| UNION, MS-TIPPAH, MS -HSA# 482 | 521 | 207,692 | 250.9 | 228.8 |
| ALCORN, MS-TISHOMINGO, MS -HSA# 498 | 425 | 153,802 | 276.3 | 228.0 |
| LEE, MS-PRENTISS, MS -HSA# 418 | 1,171 | 525,670 | 222.8 | 222.8 |
| GRENADA, MS-MONTGOMERY, MS -HSA# 502 | 327 | 134,339 | 243.4 | 217.0 |
| LAFAYETTE, MS-CALHOUN, MS -HSA# 459 | 399 | 184,774 | 215.9 | 213.9 |
| LOWNDES, MS-CLAY, MS -HSA# 461 | 598 | 333,162 | 179.5 | 189.2 |
| OKTIBBEHA, MS-WEBSTER, MS -HSA# 484 | 376 | 236,011 | 159.3 | 162.0 |
