| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| MISSISSIPPI, AR-PEMISCOT, MO -HSA# 614 | 697 | 215,885 | 322.9 | 333.0 |
| MADISON, MO -HSA# 663 | 149 | 34,453 | 432.5 | 308.9 |
| GRUNDY, MO-MERCER, MO -HSA# 683 | 208 | 42,660 | 487.6 | 289.1 |
| ST. LOUIS, MO-ST. LOUIS CITY, MO -HSA# 541 | 14,816 | 5,202,651 | 284.8 | 269.7 |
| TANEY, MO -HSA# 676 | 348 | 101,758 | 342.0 | 266.6 |
| CAPE GIRARDEAU, MO-BUTLER, MO -HSA# 563 | 2,872 | 923,058 | 311.1 | 263.7 |
| CRAIGHEAD, AR-GREENE, AR -HSA# 571 | 1,956 | 664,539 | 294.3 | 257.8 |
| JASPER (JOPLIN), MO-NEWTON, MO -HSA# 539 | 1,746 | 604,055 | 289.0 | 255.0 |
| HENRY, MO-ST. CLAIR, MO -HSA# 607 | 508 | 138,008 | 368.1 | 242.9 |
| LINN, MO -HSA# 673 | 178 | 41,726 | 426.6 | 238.0 |
| ST. CHARLES (ST. CHARLES), MO-LINCOLN, MO -HSA# 599 | 1,535 | 968,770 | 158.4 | 233.5 |
| CAMDEN, MO -HSA# 685 | 274 | 99,765 | 274.6 | 231.1 |
| VERNON, MO-CEDAR, MO -HSA# 639 | 311 | 97,224 | 319.9 | 223.8 |
| GREENE (SPRINGFIELD), MO-BARRY, MO -HSA# 549 | 4,138 | 1,631,882 | 253.6 | 221.7 |
| INDEPENDENCE, AR-HOWELL, MO -HSA# 574 | 1,212 | 413,779 | 292.9 | 217.6 |
| PETTIS, MO-SALINE, MO -HSA# 656 | 844 | 282,997 | 298.2 | 216.7 |
| LEE, IA-HANCOCK, IL -HSA# 367 | 579 | 201,973 | 286.7 | 215.9 |
| PHELPS, MO-DENT, MO -HSA# 627 | 587 | 291,345 | 201.5 | 214.6 |
| ATCHISON, MO-HOLT, MO -HSA# 678 | 143 | 38,254 | 373.8 | 213.6 |
| BUCHANAN (ST. JOSEPH), MO-NODAWAY, MO -HSA# 591 | 1,323 | 463,772 | 285.3 | 210.5 |
| COLE, MO-CALLAWAY, MO -HSA# 581 | 1,370 | 596,547 | 229.7 | 206.9 |
| LIVINGSTON, MO-CARROLL, MO -HSA# 657 | 247 | 73,370 | 336.6 | 206.5 |
| JACKSON (KANSAS CITY), MO-CLAY, MO -HSA# 548 | 6,654 | 3,335,253 | 199.5 | 204.7 |
| BOONE (COLUMBIA), MO-RANDOLPH, MO -HSA# 553 | 1,160 | 624,240 | 185.8 | 186.4 |
| ADAMS, IL-MARION, MO -HSA# 353 | 1,122 | 443,461 | 253.0 | 176.8 |
| ADAIR, MO-SCOTLAND, MO -HSA# 566 | 331 | 149,054 | 222.1 | 169.5 |
| AUDRAIN, MO-MONROE, MO -HSA# 666 | 331 | 133,139 | 248.6 | 168.0 |
