| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| YORK, NE-POLK, NE -HSA# 611 | 231 | 60,633 | 381.0 | 241.9 |
| WOODBURY (SIOUX CITY), IA-BUENA VISTA, IA -HSA# 560 | 1,844 | 629,462 | 292.9 | 229.2 |
| GREGORY, SD-TRIPP, SD -HSA# 595 | 199 | 77,291 | 257.5 | 219.5 |
| YANKTON, SD-BON HOMME, SD -HSA# 578 | 660 | 205,573 | 321.1 | 215.6 |
| MADISON, NE-ANTELOPE, NE -HSA# 577 | 523 | 196,541 | 266.1 | 207.7 |
| SCOTT BLUFF, NE-GOSHEN, WY -HSA# 580 | 571 | 221,570 | 257.7 | 195.3 |
| CUSTER, NE-VALLEY, NE -HSA# 594 | 237 | 68,428 | 346.3 | 189.3 |
| FILLMORE, NE-THAYER, NE -HSA# 658 | 145 | 39,665 | 365.6 | 186.2 |
| CHASE, NE-DUNDY, NE -HSA# 654 | 67 | 22,956 | 291.9 | 183.9 |
| ADAMS, NE-NUCKOLLS, NE -HSA# 564 | 397 | 138,150 | 287.4 | 180.6 |
| LARAMIE (CHEYENNE), WY-CHEYENNE, NE -HSA# 741 | 491 | 282,840 | 173.6 | 179.9 |
| DAWES, NE-SHERIDAN, NE -HSA# 623 | 165 | 97,011 | 170.1 | 179.0 |
| PHELPS, NE-FURNAS, NE -HSA# 616 | 180 | 57,469 | 313.2 | 168.4 |
| DOUGLAS (OMAHA), NE-DODGE, NE -HSA# 542 | 3,035 | 2,052,501 | 147.9 | 162.4 |
| LANCASTER (LINCOLN), NE-GAGE, NE -HSA# 561 | 1,429 | 907,183 | 157.5 | 150.3 |
| LINCOLN, NE-PERKINS, NE -HSA# 593 | 265 | 141,131 | 187.8 | 149.6 |
| PLATTE, NE-NANCE, NE -HSA# 651 | 196 | 123,738 | 158.4 | 148.4 |
| HALL, NE-HAMILTON, NE -HSA# 555 | 423 | 235,186 | 179.9 | 143.8 |
| RICHARDSON, NE-PAWNEE, NE -HSA# 628 | 107 | 38,053 | 281.2 | 143.7 |
| BUFFALO, NE-DAWSON, NE -HSA# 570 | 413 | 248,433 | 166.2 | 137.8 |
| NEMAHA, NE -HSA# 687 | 41 | 23,379 | 175.4 | 119.9 |
| RED WILLOW, NE-DECATUR, KS -HSA# 613 | 128 | 63,017 | 203.1 | 116.8 |
| OTOE, NE-JOHNSON, NE -HSA# 660 | 110 | 57,492 | 191.3 | 112.7 |
| HOLT, NE-BROWN, NE -HSA# 559 | 100 | 55,378 | 180.6 | 111.9 |
| CHERRY, NE -HSA# 668 | 22 | 19,146 | 114.9 | 81.8 |
