| | 1996-98 | Rate/100,000 | |
| Name | Deaths | Population | Crude | Age Adjusted | |
| GALLIA, OH-MASON, WV -HSA# 283 | 1,057 | 345,881 | 305.6 | 287.1 |
| JEFFERSON (STEUBENVILLE), OH-HARRISON, OH -HSA# 360 | 1,022 | 275,931 | 370.4 | 286.8 |
| SCIOTO, OH-ROSS, OH -HSA# 337 | 1,724 | 590,297 | 292.1 | 279.1 |
| LUCAS (TOLEDO), OH-MONROE, MI -HSA# 276 | 6,221 | 2,378,683 | 261.5 | 269.6 |
| OHIO (WHEELING), WV-BELMONT, OH -HSA# 24 | 2,073 | 599,745 | 345.6 | 264.3 |
| CABELL (HUNTINGTON), WV-BOYD, KY -HSA# 46 | 3,047 | 1,094,505 | 278.4 | 256.8 |
| COLUMBIANA, OH-HANCOCK (WEIRTON), WV -HSA# 380 | 1,523 | 515,785 | 295.3 | 256.3 |
| HANCOCK, OH-SENECA, OH -HSA# 386 | 1,034 | 386,381 | 267.6 | 252.2 |
| CUYAHOGA (CLEVELAND), OH-LAKE, OH -HSA# 288 | 14,965 | 5,418,297 | 276.2 | 245.1 |
| LICKING (NEWARK), OH-KNOX, OH -HSA# 388 | 1,294 | 552,457 | 234.2 | 240.0 |
| MUSKINGUM, OH-GUERNSEY, OH -HSA# 377 | 1,741 | 670,893 | 259.5 | 239.2 |
| WOOD (PARKERSBURG), WV-WASHINGTON, OH -HSA# 34 | 1,872 | 674,982 | 277.3 | 238.6 |
| MAHONING (YOUNG), OH-MERCER, PA -HSA# 345 | 5,228 | 1,819,913 | 287.3 | 235.9 |
| RICHLAND (MANSFIELD), OH-ASHLAND, OH -HSA# 369 | 1,302 | 542,942 | 239.8 | 230.1 |
| LORAIN (LORAIN), OH-ERIE, OH -HSA# 366 | 3,145 | 1,446,980 | 217.3 | 226.0 |
| MIAMI (PIQUA), OH-SHELBY, OH -HSA# 376 | 942 | 434,628 | 216.7 | 222.1 |
| LOGAN, OH -HSA# 398 | 314 | 137,593 | 228.2 | 219.7 |
| MARION, OH-CRAWFORD, OH -HSA# 354 | 1,361 | 621,220 | 219.1 | 219.6 |
| ALLEN (LIMA), OH-MERCER, OH -HSA# 292 | 2,096 | 878,551 | 238.6 | 219.0 |
| MONTGOMERY (DAYTON), OH-GREENE, OH -HSA# 295 | 5,283 | 2,448,465 | 215.8 | 217.9 |
| FRANKLIN (COLUMBUS), OH-DELAWARE, OH -HSA# 281 | 6,353 | 3,695,575 | 171.9 | 217.5 |
| CLARK (SPRINGFIELD), OH-CHAMPAIGN, OH -HSA# 346 | 1,275 | 552,274 | 230.9 | 214.3 |
| FAIRFIELD (LANCASTER), OH-ATHENS, OH -HSA# 368 | 1,234 | 671,356 | 183.8 | 211.7 |
| STARK (CANTON), OH-TUSCARAWAS, OH -HSA# 347 | 4,384 | 1,912,121 | 229.3 | 210.1 |
| CLINTON, OH-HIGHLAND, OH -HSA# 372 | 504 | 237,933 | 211.8 | 201.8 |
| HAMILTON (CINCINNATI), OH-BUTLER, OH -HSA# 270 | 9,007 | 4,746,174 | 189.8 | 199.4 |
| SUMMIT (AKRON), OH-MEDINA, OH -HSA# 352 | 4,526 | 2,484,238 | 182.2 | 188.0 |
| WILLIAMS, OH-DEFIANCE, OH -HSA# 356 | 687 | 383,869 | 179.0 | 171.2 |
